Research Goals
Tumor cells, immune cells, and irradiated tissues release large quantities of biologically active (and distinct) nanoscale extracellular vesicles (e.g., exosomes and microvesicles). The Jones Lab combines leading edge technologies and new methods together in a cohesive translational pipeline to investigate extracellular vesicles and other extracellular biomarkers. To perform these studies in translational assays, the Jones Lab is also dedicated to improving methods in four broad categories:
- Sample processing,
- Developing translational assays that are scalable and robust,
- Providing foundational methods and software to the research community,
- Utilizing extracellular vesicle data to better understand tumors and immune responses, and
- Establishing a foundation for next-generation EV-based personalized cancer treatment and monitoring.
The overarching goal of this research program is to leverage these advancements to perform next-generation EV-based studies for personalized cancer treatment and monitoring. Two examples of our use of this clinical pipeline are to:
- Using EVs to delineate and monitor responses to immune-based therapies that are combined with radiation, and
- Developing new ways to detect and treat cancer.
Current members
Jennifer C. Jones, MD PhD
Translational Nanobiology Section Head,
NIH Stadtman
Investigator,
NIH Distinguished Scholar
Email: jennifer.jones2@nih.gov
Michelle Luo
Post-Baccalaureate
Max Bosse
Summer Intern
Rebecca Martin
Summer Intern
